Search results for " SAHA"

Alu insertion polymorphisms in the African Sahel and the origin of Fulani pastoralists.

2017

The origin of Western African pastoralism, represented today by the Fulani nomads, has been a highly debated issue for the past decades, and has not yet been conclusively resolved.This study focused on Alu polymorphisms in sedentary and nomadic populations across the African Sahel to investigate patterns of diversity that can complement the existing results and contribute to resolving issues concerning the origin of West African pastoralism.A new dataset of 21 Alu biallelic markers covering a substantial part of the African Sahel has been analysed jointly with several published North African populations.Interestingly, with regard to Alu variation, the relationship of Fulani pastoralists to …

Performance of a rapid diagnostic test for the detection of Cryptosporidium spp. in African children admitted to hospital with diarrhea

2020

Background Cryptosporidium is a protozoan parasite that causes mild to severe diarrhoeal disease in humans. To date, several commercial companies have developed rapid immunoassays for the detection of Cryptosporidium infection. However, the challenge is to identify an accurate, simple and rapid diagnostic tool for the estimation of cryptosporidiosis burden. This study aims at evaluating the accuracy of CerTest Crypto, a commercialized rapid diagnostic test (RDT) for the detection of Cryptosporidium antigens in the stool of children presenting with diarrhoea. Methods A cross-sectional study was conducted in four study sites in Sub-Saharan Africa (Gabon, Ghana, Madagascar, and Tanzania), from…

The histone deacetylase inhibitor SAHA induces HSP60 nitration and its extracellular release by exosomal vesicles in human lung-derived carcinoma cel…

2015

// Claudia Campanella 1, 2, * , Antonella D'Anneo 3, * , Antonella Marino Gammazza 1, 2, * , Celeste Caruso Bavisotto 1, 2 , Rosario Barone 1, 2 , Sonia Emanuele 4 , Filippa Lo Cascio 1 , Emanuele Mocciaro 1 , Stefano Fais 5 , Everly Conway De Macario 6 , Alberto J.L. Macario 2, 6 , Francesco Cappello 1, 2 , Marianna Lauricella 4 1 Department of Experimental Biomedicine and Clinical Neurosciences, Section of Human Anatomy “Emerico Luna”, University of Palermo, Palermo, Italy 2 Euro-Mediterranean Institute of Science and Technology, Palermo, Italy 3 Department of Biological, Chemical and Pharmaceutical Sciences and Technologies, Laboratory of Biochemistry, University of Palermo, Palermo, Ita…

Histone deacetylase inhibition by suberoylanilide hydroxamic acid: a therapeutic approach to treat human uterine leiomyoma.

2022

Objective To evaluate the effect of inhibition of histone deacetylases (HDACs) by suberoylanilide hydroxamic acid (SAHA) treatment of human uterine leiomyoma primary (HULP) cells in vitro on cell proliferation, cell cycle, extracellular matrix (ECM) formation, and transforming growth factor β3 (TGF-β3) signaling. Design Prospective study comparing uterine leiomyoma (UL) vs. adjacent myometrium (MM) tissue and cells with or without SAHA treatment. Setting Hospital and university laboratories. Patient(s) Women with UL without any hormone treatment. Intervention(s) Myomectomy or hysterectomy surgery in women for leiomyoma disease. Main Outcome Measure(s) HDAC activity was assessed by enzyme-li…

An integrated model of condom use in Sub-Saharan African youth: A meta-analysis.

2017

Objective: We tested an integrated social–cognitive model derived from multiple theories of the determinants of young people's condom use in Sub-Saharan Africa. The model comprised seven social–cognitive antecedents of condom use: Attitudes, norms, control, risk perceptions, barriers, intentions, and previous condom use. Method: We conducted a systematic search of studies including effects between at least one model construct and intended or actual condom use in young people from sub-Saharan African countries. Fifty-five studies comprising 72 independent data sets were included and subjected to random-effects meta-analysis. Demographic and methodological variables were coded as moderators. …

Speleothem records decadal to multidecadal hydroclimate variations in southwestern Morocco during the last millennium

2017

Abstract This study presents the first well-dated high resolution stable isotope ( δ 18 O and δ 13 C ) and trace element (Mg and Sr) speleothem records from southwestern Morocco covering the last 1000 yrs. Our records reveal substantial decadal to multidecadal swings between dry and humid periods, consistent with regional paleorecords with prevailing dry conditions during the Medieval Climate Anomaly (MCA), wetter conditions during the second part of the Little Ice Age (LIA), and a trend towards dry conditions during the current warm period. These coherent regional climate signals suggest common climate controls. Statistical analyses indicate that the climate of southwestern Morocco remaine…

Extreme, wintertime Saharan dust intrusion in the Iberian Peninsula: Lidar monitoring and evaluation of dust forecast models during the February 2017…

2019

The research leading to these results has received funding from the H2020 program from the European Union (grant agreement no. 654109, 778349) and also from the Spanish Ministry of Industry, Economy and Competitiviness (MINECO, ref. CGL2013-45410-R, CGL2016-81092-R, CGL2017-85344-R, TEC2015-63832-P), the Spanish Ministry of Science, Innovation and Universities (ref. CGL2017-90884-REDT); the CommSensLab "Maria de Maeztu" Unity of Excellence (ref. MDM-2016-0600) financed by the Spanish Agencia Estatal de Investigación. Co-funding was also provided by the European Union through the European Regional Development Fund (ref. POCI-01-0145-FEDER-007690, ALT20-03-0145-FEDER-000004, ALT20-03-0145-FED…

Mobile Telephony in Sub-Saharan Africa

2007

A mobile telephone is a telecommunications device that connects its user to a network using a wireless radio wave transmission technology. In some parts of the world, mobile phones are known as cellular phones. Mobile telephones were first introduced in the mid-1980s (Marcussen, 2002; Sadeh & Sadeh, 2002; Sarker & Wells, 2003). Mobile telephony is diffusing globally due to a variety of reasons, including cost advantages in setting up the system compared to landlines, its small-sized nature, portability, and its ability to foster and enhance social relationships, among others (Plant, n.d.; Marcussen, 2002; Sadeh & Sadeh, 2002; Sarker & Wells, 2003; ITU, 2004; Anonymous, 2006)…

El Sáhara y la MPC

2007

Synopsis of Carex (Cyperaceae) from sub-Saharan Africa and Madagascar

2011

This synopsis provides a key, synonymy, lectotypification, habitat descriptions and distributions for the 81 species and six additional infraspecific taxa of Carex known from tropical and southern Africa and Madagascar. It is the first treatment of Carex including all tropical and southern temperate areas in Africa since Kukenthal's monograph of subfamily Caricoideae in 1909. © 2011 The Linnean Society of London, Botanical Journal of the Linnean Society, 2011, 166, 51–99.